医学
肾脏疾病
肥胖
疾病
重症监护医学
糖尿病
盐皮质激素受体
2型糖尿病
风险因素
减肥
心理干预
生物信息学
内科学
内分泌学
醛固酮
生物
精神科
作者
Frederik Flindt Kreiner,Philip Andreas Schytz,Hiddo J.L. Heerspink,Bernt Johan von Scholten,Thomas Idorn
出处
期刊:Biomedicines
[MDPI AG]
日期:2023-09-09
卷期号:11 (9): 2498-2498
被引量:5
标识
DOI:10.3390/biomedicines11092498
摘要
Obesity is a serious chronic disease and an independent risk factor for the new onset and progression of chronic kidney disease (CKD). CKD prevalence is expected to increase, at least partly due to the continuous rise in the prevalence of obesity. The concept of obesity-related kidney disease (OKD) has been introduced to describe the still incompletely understood interplay between obesity, CKD, and other cardiometabolic conditions, including risk factors for OKD and cardiovascular disease, such as diabetes and hypertension. Current therapeutics target obesity and CKD individually. Non-pharmacological interventions play a major part, but the efficacy and clinical applicability of lifestyle changes and metabolic surgery remain debatable, because the strategies do not benefit everyone, and it remains questionable whether lifestyle changes can be sustained in the long term. Pharmacological interventions, such as sodium-glucose co-transporter 2 inhibitors and the non-steroidal mineralocorticoid receptor antagonist finerenone, provide kidney protection but have limited or no impact on body weight. Medicines based on glucagon-like peptide-1 (GLP-1) induce clinically relevant weight loss and may also offer kidney benefits. An urgent medical need remains for investigations to better understand the intertwined pathophysiologies in OKD, paving the way for the best possible therapeutic strategies in this increasingly prevalent disease complex.
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