OLINDA/EXM 2—The Next-generation Personal Computer Software for Internal Dose Assessment in Nuclear Medicine

Abstract The OLINDA/EXM version 2.0 personal computer code was created as an upgrade to the widely used OLINDA/EXM 1.0 and 1.1 codes. This paper documents the upgrades that were implemented. New decay data and anthropomorphic and biokinetic models were implemented in the software, and the software alpha and beta tested. Agreement of doses between the OLINDA/EXM codes 1 and 2 was very good. Use of the new anthropomorphic and biokinetic models results in understandable differences between the codes. Previous models were retained in the new code, and those results were identical to those in the previous code. OLINDA/EXM 2.0 represents an upgrade from version 1, with new modeling data recommended by the international community. It standardizes internal dose calculations for dose assessments in clinical trials with radiopharmaceuticals, theoretical calculations for existing pharmaceuticals, teaching, and other purposes.