紫檀
西妥因1
白藜芦醇
医学
小胶质细胞
蛛网膜下腔出血
锡尔图因
激活剂(遗传学)
药理学
信号转导
细胞凋亡
神经保护
内科学
细胞生物学
化学
炎症
生物
下调和上调
生物化学
NAD+激酶
基因
受体
酶
作者
Zihuan Zhang,Jincheng Fang,Jia-Wang Zhou,Fei Ding,Gang Zhou,Xintong Zhao,Zong Zhuang,Yaxin Lu
摘要
Neuroinflammatory injury, oxidative insults, and neuronal apoptosis are major causes of poor outcomes after subarachnoid hemorrhage (SAH). Pterostilbene (PTE), an analog of resveratrol, has been verified as a potent sirtuin 1 (SIRT1) activator. However, the beneficial actions of PTE on SAH-induced brain injury and whether PTE regulates SIRT1 signaling after SAH remain unknown. We first evaluated the dose-response influence of PTE on early brain impairment after SAH. In addition, EX527 was administered to suppress SIRT1 signaling. The results revealed that PTE significantly attenuated microglia activation, oxidative insults, neuronal damage, and early neurological deterioration. Mechanistically, PTE effectively enhanced SIRT1 expression and promoted nuclear factor-erythroid 2-related factor 2 (Nrf2) accumulation in nuclei. Furthermore, EX527 pretreatment distinctly repressed PTE-induced SIRT1 and Nrf2 activation and deteriorated these beneficial outcomes. In all, our study provides the evidence that PTE protects against SAH insults by activating SIRT1-dependent Nrf2 signaling pathway. PTE might be a therapeutic alternative for SAH.
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