CAMDOL-enabled diastereoselective synthesis of α-substituted phosphonates

Development of a highly diastereoselective synthetic approach to α-substituted phosphonates via CAMDOL-derived P-substrates by sequential deprotonation with LiHMDS and alkylation/arylation with RI to afford a range of structurally diverse products in up to 92% yields and 99 : 1 d.r.