恶病质
医学
癌症
胰腺癌
乳腺癌
前列腺癌
生物信息学
减肥
肺癌
结直肠癌
肿瘤科
内科学
肥胖
生物
作者
Mahdi Neshan,Diamantis I. Tsilimigras,Xu Han,Hua Zhu,Timothy M. Pawlik
出处
期刊:Cells
[MDPI AG]
日期:2024-01-29
卷期号:13 (3): 252-252
标识
DOI:10.3390/cells13030252
摘要
Cachexia is a condition characterized by substantial loss of body weight resulting from the depletion of skeletal muscle and adipose tissue. A considerable fraction of patients with advanced cancer, particularly those who have been diagnosed with pancreatic or gastric cancer, lung cancer, prostate cancer, colon cancer, breast cancer, or leukemias, are impacted by this condition. This syndrome manifests at all stages of cancer and is associated with an unfavorable prognosis. It heightens the susceptibility to surgical complications, chemotherapy toxicity, functional impairments, breathing difficulties, and fatigue. The early detection of patients with cancer cachexia has the potential to enhance both their quality of life and overall survival rates. Regarding this matter, blood biomarkers, although helpful, possess certain limitations and do not exhibit universal application. Additionally, the available treatment options for cachexia are currently limited, and there is a lack of comprehensive understanding of the underlying molecular pathways associated with this condition. Thus, this review aims to provide an overview of molecular mechanisms associated with cachexia and potential therapeutic targets for the development of effective treatments for this devastating condition.
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