医学
肾脏疾病
肾
促炎细胞因子
肾素-血管紧张素系统
纤维化
炎症
内分泌学
血管紧张素II
内科学
外域
糖尿病
受体
血压
作者
Vanesa Palau,Julio Pascual,María José Soler,Marta Riera
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2019-08-01
卷期号:317 (2): F333-F342
被引量:37
标识
DOI:10.1152/ajprenal.00625.2018
摘要
It is known that the renin-angiotensin system plays a major role in the pathophysiology of cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation. ACE2 can undergo cleavage or shedding to release the catalytically active ectodomain into the circulation by a disintegrin and metalloprotease (ADAM)17, also known as TNF-α-converting enzyme. ADAM17 is involved in many pathological processes such as cancer, inflammatory diseases, neurological diseases, cardiovascular diseases, atherosclerosis, diabetes, and hypertension. Clinical and experimental studies have shown that ADAM17 is involved in chronic kidney disease (CKD) with a proinflammatory and profibrotic role, suggesting that it could be an important mediator of CKD progression. ADAM17 inhibition attenuates fibrosis and inflammation, suggesting that its inhibition may be a possible new valuable therapeutic tool in fibrotic kidney disease treatment. In addition, in renal disease, some experimental studies have demonstrated that ADAM17 is differently expressed in the kidney. Thus, ADAM17 is highly expressed in distal renal tubules and increased in the whole kidney in diabetic models. In this article, we will review the role of ADAM17 under physiological and pathological conditions. We will mainly focus on the importance of ADAM17 in the context of CKD.
科研通智能强力驱动
Strongly Powered by AbleSci AI