选择性拼接
RNA剪接
外显子
内含子
计算生物学
生物
外显子剪接增强剂
拼接因子
机制(生物学)
遗传学
剪接
前体mRNA
基因亚型
进化生物学
基因
核糖核酸
物理
量子力学
作者
Eddo Kim,Amir Goren,Gil Ast
出处
期刊:BioEssays
[Wiley]
日期:2007-12-14
卷期号:30 (1): 38-47
被引量:196
摘要
Alternative splicing is a well-characterized mechanism by which multiple transcripts are generated from a single mRNA precursor. By allowing production of several protein isoforms from one pre-mRNA, alternative splicing contributes to proteomic diversity. But what do we know about the origin of this mechanism? Do the same evolutionary forces apply to alternatively and constitutively splice exons? Do similar forces act on all types of alternative splicing? Are the products generated by alternative splicing functional? Why is "improper" recognition of exons and introns allowed by the splicing machinery? In this review, we summarize the current knowledge regarding these issues from an evolutionary perspective.
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