Estrogen-Dependent Recurrent Aggressive Angiomyxoma of The Vulva: A Surgical Enigma

Aggressive angiomyxoma is an uncommon neoplasm of undetermined origin that predominantly involves the pelvis and perineum of young females. The tumor is slow growing, locally infiltrative, and highly recurrent yet is biologically benign. In this paper, the authors report on the occurrence of aggressive angiomyxoma of the vulva in a 30-year-old female, which became aggravated in two subsequent pregnancies and required repeated excision. The presence of estrogen receptors in the tumor and its enlargement in pregnancy suggest the possibility of hormone dependence of this neoplasm. (J GYNECOL SURG 23:37)