生物
MADS箱
转录因子
基因
DNA结合蛋白
计算生物学
遗传学
基因表达调控
功能(生物学)
基因表达
细胞生物学
拟南芥
突变体
作者
Francine Messenguy,Evelyne Dubois
出处
期刊:Gene
[Elsevier]
日期:2003-10-01
卷期号:316: 1-21
被引量:269
标识
DOI:10.1016/s0378-1119(03)00747-9
摘要
In all organisms, correct development, growth and function depends on the precise and integrated control of the expression of their genes. Often, gene regulation depends upon the cooperative binding of proteins to DNA and upon protein-protein interactions. Eukaryotes have widely exploited combinatorial strategies to create gene regulatory networks. MADS box proteins constitute the perfect example of cellular coordinators. These proteins belong to a large family of transcription factors present in most eukaryotic organisms and are involved in diverse and important biological functions. MADS box proteins are combinatorial transcription factors in that they often derive their regulatory specificity from other DNA binding or accessory factors. This review is aimed at analyzing how MADS box proteins combine with a variety of cofactors to achieve functional diversity.
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