转分化
前列腺癌
流浪汉
PTEN公司
神经内分泌分化
雄激素受体
癌症研究
生物
恩扎鲁胺
癌症
生物信息学
医学
肿瘤科
内科学
PI3K/AKT/mTOR通路
信号转导
干细胞
遗传学
作者
Min Zou,Roxanne Toivanen,Antonina Mitrofanova,Nicolas Floc’h,Sheida Hayati,Yanping Sun,Clémentine Le Magnen,Daniel Chester,Elahe A. Mostaghel,Andrea Califano,Mark A. Rubin,Michael M. Shen,Cory Abate‐Shen
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2017-04-15
卷期号:7 (7): 736-749
被引量:354
标识
DOI:10.1158/2159-8290.cd-16-1174
摘要
Current treatments for castration-resistant prostate cancer (CRPC) that target androgen receptor (AR) signaling improve patient survival, yet ultimately fail. Here, we provide novel insights into treatment response for the antiandrogen abiraterone by analyses of a genetically engineered mouse (GEM) model with combined inactivation of
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