UJI AKTIVITAS ANTIINFLAMASI ASAM p-METOKSISINAMAT SISTEM SOLID LIPID NANOPARTICLES (SLN) DENGAN BASIS GEL CARBOMER ETD 2020 (Sistem SLN Setil Alkohol (10%) - Tween 80 (12%) Propilenglikol (20%))

The research objective to investigate effect of Solid lipid nanoparticles (SLN) system on p-Methoxycinnamic acid was proposed to have an antiinflamatory activity. Solid lipid nanoparticles (SLN) was greatly investigated recently as a new drug delivery system. SLN had several benefits as a topical drug carrier. The research consist of organoleptic, pH, antiinflamatory effect. The antiinflamatory effect of Solid Lipid Nanoparticles were compared with Diclofenac Na gel on carragenan induced paw edema in rats. Antiinflamtory activity test showed that antiinflamatory activity of SLN system on APMS did not gave signicant differences compared to APMS without SLN system.