厚壁菌
粪便
肠粘膜
微生物学
抗体
拟杆菌
免疫球蛋白A
免疫
免疫球蛋白G
生物
蛋白质细菌
空肠
抗菌剂
免疫系统
免疫学
细菌
内科学
医学
内分泌学
遗传学
16S核糖体RNA
作者
Teng Teng,Feng Gao,Wei He,Hong Fu,Jing Guo,Guangdong Bai,Baoming Shi
标识
DOI:10.1021/acs.jafc.0c00545
摘要
The goal of this study was to investigate the effects of early fecal microbial transfer (FMT) on the microflora of recipient piglets, where Yorkshire newborn piglets and Min sows (an indigenous pig breed in China) were used as the fecal recipients and donors, respectively, to reveal the changes in immunity and development-related functions of the intestinal mucosa driven by FMT. The recipient group was inoculated with fecal microbial fluids from days 1 to 10. On day 21, the relative abundance of the Proteobacteria was reduced; the concentrations of immunoglobulin M (IgM) and immunoglobulin G (IgG) in the jejunal mucosa, and that of IgG in the ileal mucosa of the recipient group, were increased (P < 0.05). On day 40, the relative abundance of the Firmicutes in the recipient group was increased, while that of Bacteroides was decreased. The concentrations of IgG and IgM in the ileal mucosa of the recipient group were increased. FMT protected the intestine by modulating the antimicrobial peptides of the intestinal mucosa (P < 0.05). The results of this study revealed that early FMT can improve the gut microbiota, intestinal mucosal immunity, and intestinal development-related functions of Yorkshire piglets.
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