Advancement of PI3K-mTOR signaling pathway

Previous studies have demonstrated that phosphoinositide-3-kinase/tbe mammalian target of rapamycin(PI3K-mTOR) signaling pathway can be involved in a number of cellular processes including cell proliferation, differentiation, survival, and tumor growth. This review describs the recent advances in understanding the PI3K-mTOR signaling pathway, the PI3K-mTOR inhibitors, and also the regulation and the role of PI3K-mTOR pathway. Also it sheds light on investigations between interferon-alpha and PI3KmTOR pathway. Key words: Phosphoinositide-3-kinase/the mammalian target of rapamycin; Interferon-alpha