生物医学
纳米技术
纳米颗粒
细胞毒性
细胞代谢
材料科学
生化工程
化学
体外
新陈代谢
生物信息学
生物
工程类
生物化学
作者
Hao Wu,Yangnan Hu,Junguo Wang,Xia Gao,Xiaoyun Qian,Mingliang Tang
摘要
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.
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