Pimavanserin in Dementia-Related Psychosis

Dementia occurs in a range of progressive neurodegenerative brain disorders, including Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease dementia, vascular dementia, and frontotemporal dementia, each classified according to their respective neuropathological characteristics. Dementia is clinically defined by cognitive and functional impairments and is often associated with behavioral and psychological disturbances including psychosis. The behavioral disturbances often include aggression and agitation, and symptoms of psychosis often include delusions and hallucinations that are distressing and burdensome to patients and caregivers. Estimates of the prevalence of psychosis in dementia vary among studies, with hallucinations occurring in 15 to 50% of patients with . . .