未折叠蛋白反应
酒精性肝病
内质网
炎症体
脂肪肝
非酒精性脂肪肝
炎症
脂肪变性
疾病
压力(语言学)
脂肪性肝炎
医学
肝病
酒精性肝炎
生物信息学
免疫学
生物
内科学
细胞生物学
肝硬化
哲学
语言学
作者
Cynthia Lebeaupin,Déborah Vallée,Philippe Gual,Béatrice Bailly-Maitre
出处
期刊:Journal of single cell genomics & proteomics
[OMICS Publishing Group]
日期:2016-06-01
卷期号:5 (2)
被引量:5
标识
DOI:10.4172/2168-9431.1000140
摘要
With the prevalence of obesity increasing worldwide, nonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease. Despite this, knowledge about the molecular mechanisms involved in NAFLD progression is still limited. Recent findings have shown that endoplasmic reticulum (ER) stress links inflammation and hepatocyte death, inherent to the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). Here, we emphasize the central role of the ER stress response and its crosstalk with the inflammasome. We hope to provide new insight on the identification of ER stress-dependent pathways that contribute substantially to chronic liver disease progression as important triggers of cell death and inflammation, and therefore may represent potential therapeutic strategies.
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