Acute Toxicity, Absorption and Excretion of Sulfathiazole and Certain of its Derivatives.

It has been shown that the acute toxicity of sulfathiazole (as measured by the parenteral injection of sodium salts) for mice is one-third greater than that of sulfanilamide, and about half that of sulfapyridine, sulfathiazole methyl and sulfathiazole phenyl. Sulfathiazole is absorbed more readily and is excreted more rapidly than is sulfapyridine. Because of its rate of excretion it is probable that doses of sulfathiazole spaced at intervals of 4 hours will maintain adequate concentrations of the drug in the blood of patients.