Aim To evaluate the results of first round of global fund tuberculosis control project implemented in 3 poverty-stricken counties of Nanning City.Methods Related data on regular monitoring of tuberculosis from April 2003 to March 2008 in 3 poverty-stricken counties of Nanning were collected and analyzed according to the final assessment and self-assessment questionnaires survey of first round of global fund tuberculosis control project.Results In total 8 060 active pulmonary tuberculosis patients were detected from April 2003 to March 2008 including 2 505 smear positive pulmonary tuberculosis patients.Registration rate of smear positive pulmonary tuberculosis patients raised from 11.6/100 000 in 2003 to 41.27/100 000 in 2007,which reached 121.73% of the project target.The new smear negative conversion rate of pulmonary tuberculosis patients at the end of 2 month of treatment was 85.2%.And the cure rate of new smear positive TB was 91.5%.Conclusions Marked achievements had been made in the tuberculosis control after implementation of first round of global fund tuberculosis control project in 3 poverty-stricken counties of Nanning City,but further tuberculosis control activities be continuously carried out.