Objective To compare CT angiography with 64-slice CT and digital subtraction angiography(DSA) in the diagnostic accuracy and specificity of peripheral vascular diseases.Methods Thirty patients with peripheral vascular diseases were referred for selective digital subtraction angiography(DSA)and also undergone CT angiography.Findings were graded according to 5 categories:1,normal(0% stenosis);2,mild(1%-49% stenosis);3,moderate(50%-74% stenosis);4,severe(75%-99% stenosis);5,occluded.CT angiography findings were compared with those of DSA for every equivalent arterial segment;taking the outcomes of DSA as gold standard and analizing the sensitivity and specificity etc.Results In all 30 patients,720 vessel segments were evaluated with both imaging modalities.Comparing with DSA,the sensitivity of CTA to diagnose significant stenosis was 98.5% and specificity 99.2%;with positive predictive value(PPV) of 99.1% and negative predictive value(NPV) of 98.7%.Conclusion 64-slice spiral CT angiography is an accurate,safe,noninvasive technique for diagnosing peripheral vascular stenotic diseases.