Objective:This study was carried out on groups of different physical condition,exploring the relationship between changes of gene polymorphism and BMI(body mass index)and WC(waist circumference).And on the basis it explores the effect of different levels of physical activity on BMI and the crowd WC.Method:The Han population in northern China in the subjects(age 39~79 years) were assessed for physical activity(PA),and the subjects(subjects are from the same ethnic group)height,weight,waist circumference and other indices were measured.Effects of physical activity on body mass index and waist circumference(WC) were analyzed.Conclusion:The physical activity significantly reduced the effects on BMI and WC.The effect of BMI and WC of the inactive group is greater than the active group.The findings have great in promoting significance public health,which shows that the increase in body mass index and waist circumference can be controlled lifestyle physical activity.