Clinical Characteristics of Nephrin Autoantibody-Positive Minimal Change Disease in Older Adults

Minimal change disease (MCD) is a major cause of adult-onset nephrotic syndrome, particularly in Japan where it affects 40% of patients compared with15% of patients world-wide.1 Its incidence is particularly high among the elderly and both the disease and corticosteroid therapy can be a major cause of morbidity in this population.