香豆素
生物信息学
化学
臭椿
伞形酮
菜蛾
生物测定
酪氨酸酶
立体化学
植物
生物
有机化学
生物化学
幼虫
基因
酶
遗传学
作者
Zhi-Kang Duan,Wei Xu,Mei-Ya Lian,Shan‐Shan Guo,Zhi-Heng Gao,Ming Bai,Xiao‐Xiao Huang,Shao‐Jiang Song
标识
DOI:10.1021/acs.jafc.4c01049
摘要
Demand for the exploration of botanical pesticides continues to increase due to the detrimental effects of synthetic chemicals on human health and the environment and the development of resistance by pests. Under the guidance of a bioactivity-guided approach and HSQC-based DeepSAT, 16 coumarin derivatives were discovered from the leaves of Ailanthus altissima (Mill.) Swingle, including seven undescribed monoterpenoid coumarins, three undescribed monoterpenoid phenylpropanoids, and two new coumarin derivatives. The structure and configurations of these compounds were established and validated via extensive spectroscopic analysis, acetonide analysis, and quantum chemical calculations. Biologically, 5 exhibited significant antifeedant activity toward the Plutella xylostella. Moreover, tyrosinase being closely related to the growth and development of larva, the inhibitory potentials of 5 against tyrosinase was evaluated in vitro and in silico. The bioactivity evaluation results highlight the prospect of 5 as a novel category of botanical insecticide.
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