化学
烷基化
催化作用
镍
试剂
烷基
电泳剂
还原消去
有机化学
药物化学
组合化学
作者
Qiang Chen,Jingwen You,Tian Tian,Zhenyao Li,Myuto Kashihara,Hiroki Mori,Yasushi Nishihara
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-14
卷期号:24 (50): 9259-9263
被引量:6
标识
DOI:10.1021/acs.orglett.2c03823
摘要
This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)-C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.
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