醋酸纤维素
盐酸四环素
热重分析
核化学
纳米纤维
静电纺丝
化学
傅里叶变换红外光谱
四环素
纤维素
扫描电子显微镜
细菌纤维素
聚合物
化学工程
材料科学
有机化学
生物化学
纳米技术
抗生素
复合材料
工程类
作者
M. R. Khan,Shiqin Liao,Amjad Farooq,Muhammad Awais Naeem,Muhammad Wasim,Qufu Wei
标识
DOI:10.1016/j.ijbiomac.2023.126266
摘要
Cigarette waste are pervasive litter on Earth, posing a major threat to organisms and ecosystems. However, these waste contain cellulose acetate (CA) and can be recycled, transforming into raw materials for new products. Polymers like CA can be used in biomedical applications as drug carriers and scaffolds for drug release. In this study, cigarette filters waste was collected, recycled and used for fabricating the nanofibrous membrane of cellulose acetate nanofibers (CFCA) through electrospinning technique. Tetracycline hydrochloride (TC) was encapsulated in the nanofibers to prevent bacterial infections. Various analyses were conducted: Scanning Electron Microscope (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction Analysis (XRD) and Thermogravimetric analysis (TGA). CA and CFCA exhibited high water uptake properties and exhibited similar breaking stress and strain values. Both CA and CFCA effectively acted as stable drug carriers, with sustained in vitro drug release. Antibacterial activity was demonstrated by the drug-loaded CA and CFCA nanofibers against, Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli. Based on their cytotoxicity evaluations on mouse fibroblast cells (L929), CA and CFCA fibrous mats demonstrated no cytotoxicity and similar cell viability results. Consequently, the TC-loaded nanofibers made from CA and CFCA exhibited suitable properties for wound healing applications.
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