全合成
下部结构
化学
立体化学
组合化学
纳米技术
材料科学
工程类
结构工程
作者
Katherine L. Walker,Richard P. Loach,Mohammad Movassaghi
出处
期刊:The Alkaloids: Chemistry and Biology
日期:2023-01-01
卷期号:: 159-206
标识
DOI:10.1016/bs.alkal.2023.06.002
摘要
The 2,5-diketopiperazine (DKP) motif is present in many biologically relevant, complex natural products. The cyclodipeptide substructure offers structural rigidity and stability to proteolysis that makes these compounds promising candidates for medical applications. Due to their fascinating molecular architecture, synthetic organic chemists have focused significant effort on the total synthesis of these compounds. This review covers many such efforts on the total synthesis of DKP containing complex alkaloid natural products.
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