膜
材料科学
弹性蛋白
聚氨酯
静电纺丝
壳聚糖
部分凝血活酶时间
化学工程
肿胀 的
高分子化学
生物医学工程
纳米纤维
聚合物
复合材料
凝结
化学
医学
病理
工程类
精神科
生物化学
作者
Thiviya Selvaras,Somyah Ali Alshamrani,Rathosivan Gopal,Saravana Kumar Jaganathan,Sivakumar Sivalingam,Suhaini Kadiman,Syafiqah Saidin
摘要
Abstract Current commercialized vascular membranes to treat coronary heart disease (CHD) such as Dacron and expanded polytetrafluoroethylene (ePTFE) have been associated with biodegradable and thrombogenic issues that limit tissue integration. In this study, biodegradable vascular membranes were fabricated in a structure of electrospun nanofibers composed of polyurethane (PU), chitosan (CS) and elastin (0.5%, 1.0%, and 1.5%). The physicochemical properties of the membranes were analyzed, followed by the conduction of several test analyses. The blending of CS and elastin has increased the fiber diameter, pore size and porosity percentage with the appearance of identical chemical groups. The wettability of PU membranes was enhanced up to 39.6%, demonstrating higher degradation following the incorporation of both natural polymers. The PU/CS/elastin electrospun membranes exhibited a controlled release of CS (Higuchi and first‐order mechanisms) and elastin (Higuchi and Korsmeyer‐Peppas mechanisms). Delayed blood clotting time was observed through both activated partial thromboplastin time (APTT) and partial thromboplastin time (PT) analyses where significantly delay of 26.8% APTT was recorded on the PU membranes blended with CS and elastin, in comparison with the PU membranes, supporting the membrane's antithrombogenic properties. Besides, these membranes produced a minimum of 2.6 ± 0.1 low hemolytic percentage, projecting its hemocompatibility to be used as vascular membrane.
科研通智能强力驱动
Strongly Powered by AbleSci AI