Synthesis and Cardioprotective Activity of a Novel Series of Benzoxazole Derivatives

Novel series of benzoxazole derivatives were prepared by the condensation of methyl-2-(2-aminothiazol-5-ylamino) benzo[d]oxazole-5-carboxylate with various aromatic aldehydes.The structures of the synthesized compounds were VI1-VI15 assigned on the basis of elemental analysis, IR, 1 H NMR and mass spectroscopy.These compounds were also screened for cardioprotective activity against Doxorubicin induced cardiotoxicity in rats.Selected two compounds produced a dose dependent cardioprotective activity by decreasing the doxorubicin elevated parameters like plasma Aspartate aminotransferase (AST), Creatinine kinase (CK-MB), Lactic acid dehydrogenase (LDH) and Triglyceride (TG) levels.