纳米纤维
纤维素
细菌纤维素
金属有机骨架
纳米颗粒
固定化酶
多孔性
生物催化
咪唑
自组装
纳米技术
化学
材料科学
催化作用
化学工程
酶
有机化学
反应机理
工程类
复合材料
吸附
作者
Wanning Gao,Youcong Li,Xing Zhang,Meng Qiao,Yuan Ji,Jie Zheng,Lei Gao,Shuai Yuan,Haihong Huang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-03-07
卷期号:24 (11): 3404-3412
标识
DOI:10.1021/acs.nanolett.3c05152
摘要
Assembling metal-organic frameworks (MOFs) into ordered multidimensional porous superstructures promises the encapsulation of enzymes for heterogeneous biocatalysts. However, the full potential of this approach has been limited by the poor stability of enzymes and the uncontrolled assembly of MOF nanoparticles onto suitable supports. In this study, a novel and exceptionally robust Ni-imidazole-based MOF was synthesized in water at room temperature, enabling in situ enzyme encapsulation. Based on this MOF platform, we developed a DNA-directed assembly strategy to achieve the uniform placement of MOF nanoparticles onto bacterial cellulose nanofibers, resulting in a distinctive "branch-fruit" structure. The resulting hybrid materials demonstrated remarkable versatility across various catalytic systems, accommodating natural enzymes, nanoenzymes, and multienzyme cascades, thus showcasing enormous potential as universal microbioreactors. Furthermore, the hierarchical composites facilitated rapid diffusion of the bulky substrate while maintaining the enzyme stability, with ∼3.5-fold higher relative activity compared to the traditional enzyme@MOF immobilized in bacterial cellulose nanofibers.
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