败血症
医学
病理生理学
重症监护医学
疾病
全身炎症反应综合征
弥漫性血管内凝血
炎症
免疫学
病理
作者
Jaskirat Arora,Asher A. Mendelson,Alison Fox‐Robichaud
出处
期刊:American Journal of Physiology-regulatory Integrative and Comparative Physiology
[American Physiological Society]
日期:2023-05-01
卷期号:324 (5): R613-R624
被引量:9
标识
DOI:10.1152/ajpregu.00003.2023
摘要
Sepsis, a medical emergency, is the overwhelming host response to infection leading to organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory response that stimulates a complex interaction between endothelial and complements with associated coagulation abnormalities. Despite a more comprehensive understanding of sepsis pathophysiology, there exists a translational gap to improve sepsis diagnosis clinically. Many of the proposed biomarkers to diagnose sepsis lack sufficient specificity and sensitivity to be used in routine clinical practice. There has also been a lack of progress in diagnostic tools due to the focus on the inflammatory pathway. Inflammation and coagulation are known to be linked to the innate immune response. Early immunothrombotic changes could result in the early switch from infection to sepsis and aid in sepsis diagnosis. This review integrates both preclinical and clinical studies that highlight sepsis pathophysiology providing a framework for how the development of immunothrombosis could be used as a starting point to investigate biomarkers for early sepsis diagnosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI