Review of pretreatment and analytical methods for environmental endocrine disruptors: Phthalates

Abstract Phthalates, known as phthalate esters (PAEs), are among the most ubiquitous pervasive env7ironmental endocrine disruptors (EEDs), extensively utilized globally in various facets of modern life due to their irreplaceable role as plasticizers. The exponential production and utilization of plastic goods have substantially escalated plastic waste accumulation. Consequently, PAEs have infiltrated the environment, contaminating food and drinking water reservoirs, posing notable threats to human health. This review provides a comprehensive overview of research advancements in PAE detection and identifies key focal points from 2000 to 2022, utilizing the Web of Science Core Collection. Sample pretreatment and analytical methodologies for PAEs are examined based on bibliometric analysis findings. Pretreatment methods mainly include dispersive solid-phase extraction (DSPE), magnetic solid-phase extraction (MSPE), molecularly imprinted solid-phase extraction (MISPE) and solid-phase microextraction (SPME). Laboratory analytical methods such as gas chromatography (GC), liquid chromatograph (LC) and immunoassay have been described. Additionally, a discussion on the advantages and challenges of rapid on-site detection methods, in comparison to traditional approaches, is presented in alignment with the evolving demands of PAEs detection. Based on the current research progress, future studies can focus on the demand of rapid detection of PAEs.