Synthesis of Innovative Photosensitizers for Enhanced Photodynamic Therapy of Drug-Resistant Pathogens and Biofilms

) generation to disrupt bacterial structures and functions, as well as eradicate biofilms and MRSA within biofilms. Studies in the mouse infection model indicate that C5-aPDT markedly promotes wound healing and exhibits excellent biocompatibility with a hemolysis rate of only 0.59% and minimal cell viability inhibition (2.96%) at therapeutic concentrations. To our knowledge, this is the first report that QA derivatives possess outstanding photodynamic activities, providing a unique molecular structure for the design of photosensitizers.