产热
光遗传学
产热素
褐色脂肪组织
刺激
化学
腺苷酸环化酶
内分泌学
细胞生物学
生物
内科学
脂肪组织
神经科学
医学
作者
Chad C. Doucette,Daniel Nguyen,Davide Barteselli,Sophia Blanchard,Mason Pelletier,Devesh Kesharwani,Ed Jachimowicz,Su Su,Michele J. Karolak,Aaron C. Brown
出处
期刊:iScience
[Elsevier]
日期:2023-04-01
卷期号:26 (4): 106560-106560
被引量:1
标识
DOI:10.1016/j.isci.2023.106560
摘要
Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1). Given their propensity to stimulate weight loss and promote resistance to obesity, they are a compelling interventional target for obesity-related disorders. Here, we tested whether an optogenetic approach could be used to activate UCP1-dependent thermogenesis in brown adipocytes. We generated brown adipocytes expressing a bacterial-derived photoactivatable adenylyl cyclase (bPAC) that, upon blue light stimulation, increases UCP1 expression, fuel uptake and thermogenesis. This unique system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can aid in our understanding of brown adipocyte biology and development of therapies that target obesity-related disorders.
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