A novel anti-FGFR1 monoclonal antibody OM-RCA-01 exhibits potent antitumor activity and enhances the efficacy of immune checkpoint inhibitors in lung cancer models
单克隆抗体
肺癌
癌症研究
免疫系统
免疫检查点
抗体
生物
化学
医学
免疫疗法
免疫学
肿瘤科
作者
Ilya Tsimafeyeu,Peter Makhov,Dmitriy Ovcharenko,Jonathan D. Smith,Yulia Khochenkova,A. Olshanskaya,Д. А. Хоченков
Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in carcinogenesis. Exploring the combination of the novel humanized monoclonal anti-FGFR1 antibody OM-RCA-01 and immunotherapy was intriguing due to involvement of FGFR1 in mechanisms of resistance to checkpoint inhibitors.
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(2025-6-4)
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