A highly luminescent lanthanide-functionalized covalent organic framework for rapid and specific detection of 7-methylguanine for DNA methylation assessment

A luminescent lanthanide-based COF probe (DPA/Eu@ETTA-DHTA) is designed for the first time for real-time identification of m 7 Gua, a biomarker of DNA methylation, achieving a high quenching response toward m 7 Gua with good selectivity and sensitivity.