3D-QSAR, Topomer CoMFA, Docking Analysis, and ADMET Predictio n of Thioether Pleuromutilin Derivatives as Antibacterial Agents

Background: Thioether pleuromutilin derivatives play a dominant role in the epidemic of bacterial resistance to antibacterial agent, and the novel antibacterial compounds would exhibit fresh mechanism of function. Keywords: Antibacterial agents, thioether pleuromutilin derivatives, 3D-QSAR, topomer CoMFA, molecular modeling, drug research.