The role of single nucleotide polymorphisms in GIPR gene in the changes of secretion in hormones and adipokines in patients with obesity with type 2 diabetes

The relationship between the rs2302382, rs8111428 and Glu354Gln (rs1800437) polymorphisms in GIPR (glucosedependent insulinotropic polypeptide receptor) gene and plasma levels of mediators involved in the regulation of carbohydrate metabolism in obese patients with type 2 diabetes (before and after a test breakfast) was investigated. The contribution of polymorphic variants of rs2302382, rs8111428 in GIPR gene in the predisposition to type 2 diabetes in individuals belonging to the Slavic population of Russia was found. Polymorphisms rs2302382 and rs8111428 in the GIPR gene were characterized by the nonequilibrium cohesion. The decrease in the level of expression of the GIPR gene in adipose tissue of the small intestine mesentery in the carriers of the CC genotype rs2302382 and AA rs8111428 was associated with the increase in the plasma leptin level, whereas during normal expression, the plasma content of insulin, and GIP (in persons with the genotype of the polymorphism rs2302382 and AG polymorphism rs8111428), resistin and ghrelin (in individuals with the genotype of the polymorphism rs2302382) increased. We propose the stimulating effect of GIP on the secretion of resistin, leptin and ghrelin, with an increase in insulin production in obese patients with type 2 diabetes.Issledovany vzaimosviazi polimorfizmov rs2302382, rs8111428 i Glu354Gln (rs1800437) gena retseptora gliukozozavisimogo insulinotropnogo polipeptida GIP (GIPR) s plazmennymi urovniami mediatorov, uchastvuiushchikh v reguliatsii uglevodnogo obmena u bol'nykh ozhireniem s SD 2 tipa (natoshchak i posle testovogo zavtraka). Ustanovlen vklad polimorfnykh variantov rs2302382, rs8111428 gena GIPR v formirovanie SD 2 tipa u lits, otnosiashchikhsia k vostochnoslavianskoĭ populiatsii Rossii. Okharakterizovano neravnovesnoe stseplenie mezhdu polimorfizmami rs2302382 i rs8111428 v gene GIPR. Ustanovleno, chto snizhenie urovnia ékspressii gena GIPR v zhirovoĭ tkani bryzheĭki tonkogo kishechnika u nositeleĭ genotipa SS rs2302382 i AA rs8111428 assotsiirovano s povysheniem plazmennogo urovnia leptina, togda kak pri normal'noĭ ego ékspressii registriruetsia rost plazmennogo soderzhaniia insulina, GIP (u lits s genotipom SA polimorfizma rs2302382 i AG polimorfizma rs8111428), rezistina i grelina (u lits s genotipom SA polimorfizma rs2302382). My predpolagaem stimuliruiushchiĭ éffekt GIP na sekretsiiu rezistina, leptina i grelina posredstvom uvelicheniia produktsii insulina u bol'nykh ozhireniem s SD 2 tipa.