异构化
化学
钴
催化作用
立体选择性
配体(生物化学)
恶唑啉
基质(水族馆)
立体化学
组合化学
药物化学
有机化学
生物化学
海洋学
受体
地质学
作者
Wei Wang,Shuang-Hui He,Yuqing Zhong,Jianhui Chen,Cheng Cai,Yanshu Luo,Yuanzhi Xia
标识
DOI:10.1021/acs.joc.1c03164
摘要
An efficient cobalt-catalyzed geometrical isomerization of 1,3-dienes is described. In the combination of a CoCl2 precatalyst with an amido-diphosphine-oxazoline ligand, the geometrical isomerization of E/Z mixtures of 1,3-dienes proceed in a stereoconvergent manner, affording (E) isomers in high stereoselectivity. This facile transformation features a broad substrate scope with good functional group tolerance and could be scaled up to the gram scale smoothly with a catalyst loading of 1 mol %.
科研通智能强力驱动
Strongly Powered by AbleSci AI