繁殖
下丘脑
生物
激素
人类生殖
允许的
神经肽
怀孕
内分泌学
内科学
医学
生态学
受体
解剖
遗传学
作者
Padmasana Singh,Shabana Anjum,Rai Ajit K. Srivastava,Kazuyoshi Tsutsui,Amitabh Krishna
标识
DOI:10.1016/j.yfrne.2022.100979
摘要
This article is an amalgamation of the current status of RFRP-3 (GnIH) in reproduction and its association with the nutrition and stress-mediated changes in the reproductive activities. GnIH has been demonstrated in the hypothalamus of all the vertebrates studied so far and is a well-known inhibitor of GnRH mediated reproduction. The RFRP-3 neurons interact with the other hypothalamic neurons and the hormonal signals from peripheral organs for coordinating the nutritional, stress, and environmental associated changes to regulate reproduction. RFRP-3 has also been shown to regulate puberty, reproductive cyclicity and senescence depending upon the nutritional status. A favourable nutritional status and the environmental cues which are permissive for the successful breeding and pregnancy outcome keep RFRP-3 level low, whereas unfavourable nutritional status and stressful conditions increase the expression of RFRP-3 which impairs the reproduction. Still our knowledge about RFRP-3 is incomplete regarding its therapeutic application for nutritional or stress-related reproductive disorders.
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