经皮失水
耐受性
红斑
医学
皮肤屏障
不利影响
皮肤温度
治疗效果
麻醉
泌尿科
内科学
皮肤病科
病理
角质层
作者
Na‐Eun Lee,Yeong‐Hun Kang,Soon‐Young Song,Seung Joon Baek,Cheol‐Yong Hwang
摘要
Abstract Background Cold atmospheric microwave plasma (CAMP) is a promising therapeutic option for treating skin infections and wounds. Changes in biophysical skin parameters and the tolerability in dogs after applying CAMP is unknown. Objective This study aimed to evaluate the in vivo effects of CAMP on skin biophysical parameters [hydration, transepidermal water loss (TEWL) and surface temperature] and tolerability in dogs. Animals Twenty client‐owned dogs with normal skin. Materials and methods Cold atmospheric microwave plasma treatment was performed for 30 s and 1, 2 and 4 min, respectively, at different sites of normal canine skin in the inguinal area. Hydration, TEWL and surface temperature were measured five, three and three times, respectively, before and after CAMP application. After treatment, pain and adverse effects were evaluated using a modified Melbourne Pain Scale and the modified short form Glasgow Composite Measure Pain Scale (modified CMPS‐SF). Results Transepidermal water loss values significantly decreased with 4 min of treatment, and hydration decreased significantly with 2 min of treatment. Temperature increased significantly with increasing treatment time. For other parameters, no significant changes were observed. No significant pain response or adverse effects were observed in most dogs, aside from mild erythema in the treatment area after 4 min. Conclusion and clinical significance Cold atmospheric microwave plasma treatment was well‐tolerated and did not significantly change canine skin biophysical parameters. CAMP achieves basic recommendations for safe use and is a potential therapeutic option for various skin diseases in dogs.
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