外显子
分子生物学
基因
生物
外周血单个核细胞
半胱氨酸蛋白酶
半胱氨酸蛋白酶3
基因组DNA
半胱氨酸蛋白酶2
抄写(语言学)
蛋白酶
信使核糖核酸
遗传学
细胞凋亡
生物化学
酶
体外
程序性细胞死亡
语言学
哲学
作者
Leopold Eckhart,Christian Kittel,Sonja Gawlas,Флориан Грубер,Michael Mildner,Bernd Jilma,Erwin Tschachler
标识
DOI:10.1016/j.bbrc.2006.07.104
摘要
Caspase-5 is a caspase-1-like protease with pro-apoptotic and pro-inflammatory activities. Here we have identified a novel exon at the 5'-end of the human caspase-5 gene. This novel exon was present in six alternatively spliced caspase-5 mRNA variants expressed in human peripheral blood mononuclear cells (PBMC) and encoded the previously unknown amino-terminus of caspase-5. The genomic region upstream of this exon contained sequence elements homologous to those of the caspase-11 promoter in the mouse, and transcription of caspase-5 was upregulated by lipopolysaccharide (LPS) in a caspase-11-like manner in human PBMC in vivo. Taken together, our findings call for a revision of the structure of caspase-5 at the genomic level as well as at the mRNA and protein levels.
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