Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity. Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity