氨基酸
化学
片段(逻辑)
领域(数学分析)
肽
组合化学
氨基酸残基
固相合成
计算生物学
生物化学
肽序列
立体化学
生物
计算机科学
算法
数学分析
数学
基因
作者
Yves-Marie Coı̈c,Charlotte Le Lan,Jean‐Michel Neumann,Nadège Jamin,Françoise Baleux
摘要
This work contributes to highlight the benefits of pseudoproline dipeptides introduction in difficult SPPS. We show how a slight modification in the positioning choice conditioned the synthesis achievement of a 54 amino acid long caveolin-1 peptide encompassing the intramembrane domain. Furthermore, we report a side reaction correlated with the coupling steps and generating truncated fragments with a mass deviation of + 42 Da. Considering the need of structural data for membrane proteins, most of which are considered as prevalent therapeutic targets, chemical synthesis provides an interesting alternative pathway to obtain hydrophobic domains by pushing back the frontiers of conventional RP methods of purification.
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