Treatment of Dextromethorphan Dependence with Naltrexone

Dextromethorphan has been described as one of the most abused dissociative drugs of abuse in America, yet many clinicians are unaware of its potential for abuse and addiction. A case is presented herein supporting the syndrome of dextromethorphan dependence (addiction), describing this drug's unique pharmacological profile, summarizing what little is known about its associated use, and providing the first known description in the peer-reviewed medical literature of the use of an established anti-relapse medication to treat this medical disease.