骨形态发生蛋白2
脚手架
再生(生物学)
细胞生物学
骨愈合
遗传增强
基因传递
体内
干细胞
组织工程
生物医学工程
材料科学
体外
化学
医学
基因
解剖
生物
生物化学
生物技术
作者
Caroline M. Curtin,Erica G. Tierney,Kevin McSorley,Sally‐Ann Cryan,Garry P. Duffy,Fergal J. O’Brien
标识
DOI:10.1002/adhm.201400397
摘要
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.
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