效应器
免疫系统
免疫学
肥大细胞
过敏
生物
获得性免疫系统
先天免疫系统
周边公差
先天性淋巴细胞
免疫耐受
作者
Martin Metz,Marcus Maurer
标识
DOI:10.1016/j.it.2007.03.003
摘要
Mast cells are best known for their potent effector functions in allergic disorders. In recent years, however, mast cells have been identified to be involved in a surprisingly complex range of immune functions that go far beyond allergies and include the development of autoimmune disorders and peripheral tolerance, and the initiation and maintenance of adaptive and innate host responses. Here, we review the key signals and effector mechanisms that have lately been identified for mast cell functions in these immune responses. Mast cells are best known for their potent effector functions in allergic disorders. In recent years, however, mast cells have been identified to be involved in a surprisingly complex range of immune functions that go far beyond allergies and include the development of autoimmune disorders and peripheral tolerance, and the initiation and maintenance of adaptive and innate host responses. Here, we review the key signals and effector mechanisms that have lately been identified for mast cell functions in these immune responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI