High-Dose UDCA Isn’t Effective in Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is an uncommon cause of chronic liver disease; however, it can be associated with liver failure and cholangiocarcinoma. No effective medical therapy for PSC is known. Results from small pilot studies have suggested that ursodeoxycholic acid (UDCA) is effective in PSC. In this large, randomized, double-blind, multicenter Scandinavian study, researchers evaluated the effectiveness of …