Endoscopic ultrasonographic investigation (EUSI) was performed in 12 patients with duodenal major papilla cancer, to whom the performance of radical surgical intervention was planned. In 9 patients the diagnosis, according to the EUSI data, was confirmed, in 1--cancer of pancreatic head was diagnosed, in 1--adenoma of duodenal major papilla, in 1--false-negative result was obtained Results of investigation was confirmed intraoperatively and according to the histological investigation data. Application of EUSI have permitted to determine correctly before the operation the stage of the disease in 8 of 9 patients. The method may be applied for verification of the diagnosis in patients with cancer of duodenal major papilla