Heck‐Type Cross‐Dehydrogenative Coupling Reactions of Indolizines at the 3‐Position with Electron‐Deficient Alkenes through Palladium‐Catalyzed CH Activation

A cross-dehydrogenative coupling reaction of indolizines with electron-deficient alkenes for the synthesis of 3-alkenyl-substituted indolizines has been reported. The reaction takes place at the 3-position selectively through palladium-catalyzed CH activation, following a Heck-type cross-coupling reaction under mild and ligand-free conditions. Furthermore, the reaction mechanism of the PdII/Pd0 catalytic pathway was also confirmed by 1H NMR spectroscopy. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.