Objective The characteristic and prognosis of great area brain infarction was discussed from the different cause.Methods 31 patients were performed decompressive craniectomy with the great area brain infarction from the different cause.Results 15 patients were died.The mortality rate is 48.4%.Among this,trauma brain infarction mortality rate is 37.5%.Spontaneous brain infarction mortality rate is 36.4%;The mortality rate which the ruptured of internal carotidartery was ligated is 80%.Conclusion The role and prognosis of decompressive craniectomyis is different in great area brain infarction from different cause.