Stability of neogambogic acid SLN in rat plasma

Aim To detect the stability of solid lipid nanoparticle in rat plasma.Methods Through detecting and contrasting the leakage rate of neo-gambogic acid reference solution and neo-gambogic acid SLN by HPLC,the stability of neo-gambogic acid SLN in rat plasma was examined.Results The leakage rate of neo-gambogic acid reference solution was 71.2%,and the neo-gambogic acid SLN was 38.5%.Conclusion Neo-gambogic acid SLN has higher stability than neo-gambogic reference solution.